Irf3 phosphorylation antibody
WebMar 4, 2024 · IRF3 is a transcriptional factor that mediates expression of a large array of genes after viral infection. We hypothesized that DUBs might regulate the activity or stability of IRF3 and thereby facilitate or inhibit cellular antiviral responses. Web该IRF3 Polyclonal Antibody. This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha …
Irf3 phosphorylation antibody
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WebPhospho-IRF3 (Ser396) Antibody (MA5-14947) in WB Frontiers in microbiology 2024 - FIGURE 2 Effects of Set-Met on the expression of MAVS protein and the phosphorylation … WebKnockout Tested Rabbit recombinant monoclonal IRF3 antibody [EPR2418Y]. Validated in WB, IHC, ICC/IF, Flow Cyt (Intra) and tested in Mouse, Human. ... DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization ...
WebTBK1-dependent phosphorylation of IRF3 leads to its nuclear translocation and subsequent activation of transcriptional programs that ultimately lead to ... for 2 h at RT or over-night at 4°C. Primary antibodies used include: anti-pDNA-PKcs Ser2056 (ab124918, Abcam), anti-pDNA-PKcs Ser2056 (ab18192, Abcam) for mouse cell lines, anti-DNA-PKcs ... WebNov 29, 2024 · This phosphorylation event causes IRF3 to dimerize, translocate into the nucleus, and induce the expression of IFN-β. IFN-β then induces the expression of IFN-stimulated genes (ISGs) through...
WebAll mutants lacked phosphorylation of the STING-S365 residue, IRF3, and STAT1 upon stimulation, indicating defects in IRF3 activation and type I IFN signaling (Fig. 1A and SI Appendix, Fig. S1A). Consistently, all mutants were deficient in IRF3 nuclear translocation ( Fig. 1 B and SI Appendix , Fig. S1 B ) and did not produce IFNβ after DMXAA ... WebViral infection results in phosphorylation of IRF3, leading to its translocation to the nucleus, where it activates promoters containing IRF3-binding …
WebMar 12, 2015 · IRF3 activation requires phosphorylation, dimerization and nuclear translocation. However, the mechanisms for the termination of IRF3 activation in nucleus are elusive. Here we report the identification of TRIM26 to negatively regulate IFN-β production and antiviral response by targeting nuclear IRF3.
WebMar 6, 2012 · Aliquots of the cell lysates were analyzed by Western blotting with an antibody against IRF3 after native PAGE (top). Data are from a single experiment representative of … songsterr livin on prayerWeb(C,D) 4b(Δ2-38) inhibits the phosphorylation and nuclear translocation of IRF3. Experiments were carried out as in AB, except that 4b(Δ2-38) was accessed. Source publication songsterr listen to the musicWebAntibodies that detect IRF3 can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry, Flow Cytometry and Peptide array. These antibodies target IRF3 in Human, Mouse, Rat, Non-human primate and Porcine samples. Our IRF3 monoclonal, polyclonal, recombinant monoclonal and recombinant ... songsterr joe satriani made of tearsWeb), the data reported here suggest that additional signals stimulate phosphorylation of IRF3 and IRF7, essential events in induction of the protective IFN response. This evidence is … songsterr mastodon the sparrowWebPrimary Anti-IRF3 (phospho S386) antibody [EPR2346] - BSA and Azide free (ab182859) Protein Recombinant Human IRF3 protein (ab205216) View more associated products Overview Product name Anti-IRF3 (phospho S386) antibody [EPR2346] See all IRF3 primary antibodies Description Rabbit monoclonal [EPR2346] to IRF3 (phospho S386) Host … songsterr man in the boxsongsterr mr crowleyWebKey features and details Rabbit polyclonal to IRF3 (phospho S396) Suitable for: WB Reacts with: Human Isotype: IgG You may also be interested in Primary Anti-IRF3 (phospho S386) … songsterr love of god