Phospho-sting-s366

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August undefined, 2024

WebProduct Description. This Cell Signaling Technology antibody is conjugated to Alexa Fluor ® 488 fluorescent dye and tested in-house for direct flow cytometric and immunofluorescent analysis in human cells. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated Phospho-STING (Ser366) (D8K6H) Rabbit mAb #40818. WebFeb 7, 2024 · TBK-independent phosphorylation of STING(S366) and its adaptor molecule TICAM2 by phospho-AKT(T308S473) augmented downstream IRF3-dependent IDO1 transcription, which was also dependent on β-catenin.

Phosphorylation of innate immune adaptor proteins …

WebStimulator of interferon genes (STING, TMEM173, MITA) is a transmembrane adaptor protein that is a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA (1,2). STING is a ubiquitously expressed protein found predominantly in the ER (1). The enzyme cGAMP synthase (cGAS) produces the second messenger cyclic … WebThe Phospho-STING (Ser366) assay uses 2 labeled antibodies: one with a donor fluorophore, the other one with an acceptor. The first antibody is selected for its specific … rcp in flessione plantare

Phospho-STING (Ser366) cellular HTRF kit Cisbio

WebPhosphorylated S366 is a docking site for IRF3 and is essential for the subsequent induction of Interferons (IFNs) ( 7, 8 ). Our previous work demonstrated that IRF3 binds to phosphorylated STING in the late endosomal compartment, where TBK1 phosphorylates and activates IRF3 ( 9 ). Additional proteins regulate the trafficking of STING. WebSTING (human) S366-p. 19781 : Phospho-STING (Ser366) (D7C3S) Rabbit mAb WebCell Signaling Technology's Phospho-STING (Ser366) (D7C3S) Rabbit mAb is a Rabbit monoclonal antibody. The Phospho-STING (Ser366) (D7C3S) Rabbit mAb Antibody was generated using stimulator of interferon response cGAMP interactor 1, and STING1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such … sims first person

Targeting the DNA damage response enhances CD70 CAR-T cell …

Phospho-TMEM173/STING (Ser366) Antibody Affinity Biosciences

WebOct 1, 2024 · Phosphorylation of S358 enables TBK1 to bind STING. TBK1 then trans-phosphorylates S366 of neighboring STING complexes, allowing the recruitment ... [138]. Paradoxically, introduction of the phospho-mimic S366D also strongly reduces IRF3 dimerization and IFN I production [163, 164]. This may be due to clearance of … WebAnti-Phospho-STING-S365 antibody produced in rabbit; find Sigma-Aldrich-SAB5701942 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich ... Anti-Phospho-TMEM173-S366 antibody produced in rabbit. View Price and Availability. ... Anti-phospho-Smad2/3 (pThr 8) antibody produced in rabbit. affinity ... rcp indocollyreWebFeb 15, 2024 · Here, we investigated the relationship between cGAS and phospho-STING (S366) protein expression levels in treatment-naïve LUAD tumors from the MD Anderson Cancer Center (MDACC) PROSPECT trial (n=120). As expected, phospho-STING (S366) protein levels were significantly correlated with cGAS protein levels (p=0.010) (Figure 1A). sims floor plans

"WebPhospho-STING (Ser366) Antibody (PA5-117276) in WB Western blot analysis of extracts of THP-1 cells using Phospho-STING (Ser366) Polyclonal Antibody ( Product # PA5-117276 … " - Phospho-sting-s366

Phospho-sting-s366

(19781) Phospho-STING (Ser366) (D7C3S) Rabbit mAb

WebThe antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns. Storage: … WebPhospho-STING (Ser366) two-plate assay protocol. The two-plate protocol involves culturing cells in a 96-well plate before lysis then transferring lysates to a low volume detection plate (either HTRF 384-lv or 96-lv plate) before adding HTRF Phospho-STING (Ser366) detection reagents. This protocol enables the cells' viability and confluence to ...

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WebPhospho-STING (Ser366) (E9A9K) Rabbit mAb recognizes endogenous levels of STING protein only when phosphorylated at Ser366. Species Reactivity: Human Source / Purification Monoclonal antibody is produced … WebApr 6, 2024 · STING is a transmembrane dimeric protein that is located in the endoplasmic reticulum or in the Golgi apparatus. ... Binding of TBK1 to this motif promotes the …

WebPhospho Sting S366, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 2 PubMed citations. ZERO BIAS - scores, article …

WebPhospho-STING (Ser366) (E9A9K) Rabbit mAb from Cell Signaling Technology Supplier PageView Company Product Page Product Specs Company Info Reviews Back To Top … Web靶标信息. STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF …

WebThe work by Lehmann et al classified TNBC into six subtypes in 2011. 5 Following this, two studies at our center further identified four transcriptome-based subtypes in TNBC: luminal androgen receptor (LAR), immunomodulatory (IM), basal-like immune-suppressed (BLIS), and mesenchymal-like (MES). 6 7 Furthermore, several reports have also …

WebWestern blot - Phospho-STING/TMEM173-S366 Rabbit pAb (AP1223) Western blot analysis of THP-1, using Phospho-STING/TMEM173-S366 … rcp inspectionWeb55. A method of treating, inhibiting, reducing, ameliorating, and/or preventing a cancer and or metastasis in a subject comprising administering to a subject an adoptive immunothe rcp in buildingWebPhospho-TMEM173/STING (Ser366) Antibody Phospho-TMEM173/STING (Ser366) Antibody - #AF7416 (6) (9) WB IHC IF/ICC pElisa Cites 1 /9 Western blot analysis of extracts from UV treated RAW264. View similar products>> Related products Secondary Antibodies Loading Controls Blocking Peptides Cat.#S0018 Cat.#S0006 Cat.#S0008 Cat.#S0001 Cat.#S0013 … sims fish and chips skewenWebJan 29, 2015 · STING S366 phosphorylation after HT-DNA transfection was detected with the p-S366 antibody (fig. S8E). ( E ) S366 phosphorylation of endogenous STING in THP-1 … sims fishing cheatWeb(19781) Phospho-STING (Ser366) (D7C3S) Rabbit mAb Sign in or register to save this reagent to your favourites Supplier Cell Signaling Technology Host Rabbit Type Primary … sims foods incPhospho-STING (Ser366) (D7C3S) Rabbit mAb recognizes endogenous levels of STING protein only when phosphorylated at Ser366. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser366 of human STING protein. Background rcp in murrietaWebApr 6, 2024 · Binding of TBK1 to this motif promotes the phosphorylation of S366 in the STING tail 19, which subsequently recruits and promotes the phosphorylation of the transcription factor interferon... rcp in the army